New Study: Liquid Green-Lipped Mussel with Bio-Curcumin good alternative in low back pain

Belgian researchers: less pain and more quality of life

Liquid Green-lipped mussel with Bio-Curcumin and Blackcurrant leaf is a promising therapy for low back pain and possibly other rheumatic conditions. This is the result of a new retrospective observation study. In the case of these types of studies, medical records are examined afterwards to review the efficacy of the used medicine. This study was conducted by the Department of Rheumatology and Physical Medicine of Iris Hospital South and the Emergency Department of Erasmus University Hospital in Brussels. The efficacy of this liquid joint cure was considered “sufficient”. This study was published in May 2017 in the ‘Open Journal of Rheumatology and Autoimmune Diseases’.

Low back pain often chronic

New study
Osteoarthritis and especially low back pain are one of the most common health problems reported by patients. Low back pain occurs in different age groups and is often chronic. Patients often experience insufficient effects upon regular treatment. Therefore, they are looking for alternative therapies. In this study, the treatment in patients with low back pain consisted of 2 to 3 capsules of liquid Green-lipped mussel with Bio-Curcumin (BCM-95®) and Blackcurrant leaf per day for 1 to 3 months. This retrospective observation study was conducted on the basis of the experience of 5 rheumatologists. These specialists provided medical records of patients with chronic low back pain treated with liquid Green-lipped mussel with Bio-Curcumin and Blackcurrant leaf for at least 3 months. The average age was 69 years and the gender ratio was 24 percent men and 61 percent women. The duration of the low back pain was on average 54 months. The researchers collected all data on pain, severity of complaints, results and side effects from 85 medical records. In particular, the results of the Dallas Pain Questionnaire were reviewed. This questionnaire is a quick and easy tool to determine the severity of pain in the back.

Strong decrease in pain

The researchers compared the data collected from the medical records at three time points: before the start of treatment, after six weeks and after three months. The treatment with liquid Green-lipped mussel, Bio-Curcumin and Blackcurrant leaf caused a sharp decrease in pain in the first six weeks. This benefit lasted until the last measuring point of three months. Within six weeks after the start of treatment, the quality of life also increased significantly. The need for painkillers decreased and less help was needed in daily care, such as tooth brushing, dressing and going to bed. In addition, patients were better able to raise things. The efficacy of liquid Green-lipped mussel with Bio-Curcumin and Black berry leaf was evaluated as “moderate” to “good” after six weeks. This score increased slightly by the end of the three-month investigation period. No side effects were reported. Only 2 out of 85 patients reported mild diarrhea at the start of treatment and 3 patients had difficulty swallowing the capsules.

Explanation of authors

This retrospective study is based on the clinical experience of 5 rheumatologists and the medical records of 85 patients with chronic low back pain. Treatment with liquid Green-lipped mussel with Bio-Curcumin and Blackcurrant leaf not only reduced the pain, but also the need to use anti-inflammatory analgesics. The negative effect of chronic low back pain on daily life also decreased. This natural remedy gave the patients a greatly improved quality of life. This benefit was achieved in the first 6 weeks of therapy and continued until the end of the three-month study period. Liquid Green-lipped mussel with Bio-Curcumin and Blackcurrant leaf is therefore a real alternative to analgesic or anti-inflammatory drugs usually prescribed in low back pain.


Qu, J.; Mélot, Ch.; Appelboom, Th. (2017) Synofit Premium in refractory low back pain: a retrospective observational study. Open Journal of Rheumatology and Autoimmune Diseases 7;120-127.

The entire (English) publication of this study is available online through the site of the Open Journal of Rheumatology and Autoimmune Diseases.

Previous study

This study is the follow-up to an earlier study of this product. The previous study can be found on the page on our site with the results of the first survey.


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